Moreover, scientists are usually careful to characterize the veridical status of their attempts to understand the world - ranging from conjectures and hypotheses, which are highly tentative, all the way up to laws of Nature which are repeatedly and systematically confirmed through many interrogations of how the world works. But even laws of Nature are not absolutely certain. There may be new circumstances never before examined - inside black holes, say, or within the electron, or close to the speed of light - where even our vaunted laws so Nature break down and, however valid they may be in ordinary circumstances, need correction.
Humans may crave absolute certainty; they may aspire to it; they may pretend, as partisans of certain religsion do, to have attained it. But the history of science - by far the most successful claim to knowledge accessible to humans - teaches that the most we can hope for is successive improvement in our understanding, learning from our mistakes, an asymptotic approach to the Universe, but with the proviso that absolute certainty will always elude us… …
Because science carries us toward an understanding of how the world is, rather than how we would wish it to be, its findings may not in all cases be immediately comprehensible or satisfying. It may take a little work to restructure our mindsets. Some of science is very simple. When it gets complicated, that’s usually because the world is complicated - or because we’re complicated.
~ Carl Sagan, The Demon-Haunted World